E6201 [603987-35-5]

MedChem Express

E6201 [603987-35-5]

10

603987-35-5

Research Use Only

C21H27NO6

389.44

E6201 (ER-806201) is an ATP-competitive dual kinase inhibitor of MEK1 and FLT3. E6201 inhibits MEK1- induced ERK2 phosphorylation with an IC50 value of 5.2 nM, MKK4-induced JNK phosphorylation with an IC50 value of 91 nM, and MKK6-induced p38 MAPK phosphorylation with an IC50 value of 19 nM. Anti-tumor and anti-psoriasis efficacy[1][2].

OC1=C2C(/C=C/C[C@@H]([C@@H](C(/C=C\[C@H]([C@@H](OC2=O)C)C)=O)O)O)=CC(NCC)=C1

12352200