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E7449

M5267
AbMole BioScience
CAS Number1140964-99-3
DownloadDatasheet
Product group Chemicals
Estimated Purity>98%
Molecular Weight317.34
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    E7449
  • Delivery Days Customer
    9
  • CAS Number
    1140964-99-3
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C18H15N5O
  • Molecular Weight
    317.34
  • Scientific Description
    E7449 is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 that also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/bèta-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively.
  • SMILES
    O=C1NN=C2NC(=NC3=C2C1=CC=C3)CN4CC5=C(C4)C=CC=C5
  • UNSPSC
    12352200

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