E7820

MedChem Express

E7820 [289483-69-8]

10

289483-69-8

Research Use Only

99.06

C17H12N4O2S

336.37

E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC 50 of 0.11 microg/ml. E7820 modulates alpha-1, alpha-2, alpha-3, and alpha-5 integrin mRNA expression. Antiangiogenic and antitumor activity [1] [2] .

O=S(C1=CC(C#N)=CC=C1)(NC2=C(NC=C3C#N)C3=C(C)C=C2)=O

-20°C,2°C to 8°C

12352200