Edicotinib (hydrochloride) [1559069-92-9]
HY-109086A
CAS Number1559069-92-9
Product group Chemicals
Molecular Weight498.06
Overview
- SupplierMedChem Express
- Product NameEdicotinib (hydrochloride) [1559069-92-9]
- Delivery Days Customer9
- CAS Number1559069-92-9
- CertificationResearch Use Only
- Molecular FormulaC27H36ClN5O2
- Molecular Weight498.06
- Scientific DescriptionEdicotinib hydrochloride is a potent, selective, brain penetrant and orally active colony-stimulating factor-1 receptor (CSF-1R) inhibitor with an IC50 of 3.2 nM. Edicotinib hydrochloride exhibits less inhibitory effects on KIT and FLT3 with IC50 values of 20 nM and 190 nM, respectively[1]. Edicotinib hydrochloride limits microglial expansion and attenuates microglial proliferation and neurodegeneration in mice. Edicotinib hydrochloride has the potential for Alzheimers disease and rheumatoid arthritis research[1][2].
- SMILESO=C(C1=NC=C(C#N)N1)NC2=C(C3=CCC(C)(C)CC3)N=C(C(CC(C)(C)O4)CC4(C)C)C=C2.Cl
- UNSPSC12352200