EED226

MedChem Express

EED226 [2083627-02-3]

9

2083627-02-3

99.56

C17H15N5O3S

369.40

EED226 is a polycomb repressive complex 2 ( PRC2 ) inhibitor, which binds to the K27me3-pocket on embryonic ectoderm development ( EED ) and shows strong antitumor activity in xenograft mice model [1] . EED226 is a potent, selective, and orally bioavailable EED inhibitor [2] . EED226 inhibits PRC2 with an IC 50 of 23.4 nM when the H3K27me0 peptide is used as a substrate in the in vitro enzymatic assays [3] .

O=S(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)(C)=O

-20°C,2°C to 8°C

12352200