EEDi-5273

Biorbyt

EEDi-5273 [2585648-55-9]

10

2585648-55-9

Research Use Only

C26H22F4N6O2

526.49

EEDi-5273 is an exceptionally potent and orally efficacious embryonic ectoderm development (EED) inhibitor with IC50 of 0.2 nM and inhibits the KARPAS422 cell growth with IC50 of 1.2 nM. EEDi-5273 demonstrates an excellent PK and ADME profile, and its oral administration leads to complete and persistent tumor regression in the KARPAS422 xenograft model with no signs of toxicity.

FC1C=CC2=C(CCO2)C=1CNC1=NC=C2C3=CN=C(C(F)(F)F)C=C3CN(C(C3=C2N1C=N3)=O)C(C)C

12352200