EEF1A2 antibody
GTX102326
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat, Zebra Fish
TargetEEF1A2
Overview
- SupplierGeneTex
- Product NameEEF1A2 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.21 mg/ml
- ConjugateUnconjugated
- Gene ID1917
- Target nameEEF1A2
- Target descriptioneukaryotic translation elongation factor 1 alpha 2
- Target synonymsDEE33, EEF1AL, EF-1-alpha-2, EF1A, EIEE33, HS1, MRD38, STN, STNL, elongation factor 1-alpha 2, eukaryotic elongation factor 1 A-2, statin-S1
- HostRabbit
- IsotypeIgG
- Protein IDQ05639
- Protein NameElongation factor 1-alpha 2
- Scientific DescriptionThis gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
- ReactivityHuman, Mouse, Rat, Zebra Fish
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Xu Y, Kusuyama J, Osana S, et al. Lactate promotes neuronal differentiation of SH-SY5Y cells by lactate-responsive gene sets through NDRG3-dependent and -independent manners. J Biol Chem. 2023,299(6):104802. doi: 10.1016/j.jbc.2023.104802Read this paper
- Hassan MK, Kumar D, Patel SA, et al. EEF1A2 triggers stronger ERK mediated metastatic program in ER negative breast cancer cells than in ER positive cells. Life Sci. 2020,262:118553. doi: 10.1016/j.lfs.2020.118553Read this paper
- Hassan MK, Kumar D, Patel SA, et al. Expression pattern of EEF1A2 in brain tumors: Histological analysis and functional role as a promoter of EMT. Life Sci. 2020,246:117399. doi: 10.1016/j.lfs.2020.117399Read this paper
- Losada A, Muñoz-Alonso MJ, Martínez-Díez M, et al. Binding of eEF1A2 to the RNA-dependent protein kinase PKR modulates its activity and promotes tumour cell survival. Br J Cancer. 2018,119(11):1410-1420. doi: 10.1038/s41416-018-0336-yRead this paper
- Barbé C, Bray F, Gueugneau M, et al. Comparative Proteomic and Transcriptomic Analysis of Follistatin-Induced Skeletal Muscle Hypertrophy. J Proteome Res. 2017,16(10):3477-3490. doi: 10.1021/acs.jproteome.7b00069Read this paper
- Losada A, Muñoz-Alonso MJ, García C, et al. Translation Elongation Factor eEF1A2 is a Novel Anticancer Target for the Marine Natural Product Plitidepsin. Sci Rep. 2016,6:35100. doi: 10.1038/srep35100Read this paper
- Doig J, Griffiths LA, Peberdy D, et al. In vivo characterization of the role of tissue-specific translation elongation factor 1A2 in protein synthesis reveals insights into muscle atrophy. FEBS J. 2013,280(24):6528-40. doi: 10.1111/febs.12554Read this paper
Datasheet
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