EF-1502 [684645-54-3]

MedChem Express

EF-1502 [684645-54-3]

9

684645-54-3

Research Use Only

C22H26N2O2S2

414.58

EF-1502 is a potent and selective GABA transporter inhibitor with GAT1 and BGT1 inhibitory activity. EF-1502 produces a synergistic anti-epileptic effect when used in combination with Tiagabine (HY-B0696), a compound used to suppress epileptic seizures. The dosing combination of EF-1502 exhibited reduced anti-epileptic efficacy and dyskinesia when used with THIP (HY-10232). The mechanism of EF-1502 differs significantly from Tiagabine, suggesting a unique role in the inhibitory strategy[1].

OC1=NOC2=C1C(CCC2)N(C)CC/C=C(C3=C(C=CS3)C)\C4=C(C=CS4)C

12352200