EGFR-IN-154

MedChem Express

EGFR-IN-154

5

Research Use Only

C20H21N5O2

363.41

EGFR-IN-154 (compound 4c) is an EGFR inhibitor with EC50 values of 0.16 microM, 21.73 microM and 41.56 microM against EGFR Del19, EGFR WT and EGFR L858R, respectively. EGFR-IN-154 shows anticancer activity on various cance cell lines. EGFR-IN-154 induces mitochondrial apoptosis, and decreases pERK1/2 and pAkt levels, but increases pJNK and pp38 levels[1].

N=C(NC1CC1)C(C=C2)=CC=C2NC3=NC=NC4=C3C=C(OC)C(OC)=C4

12352200