EGFR-IN-42

MedChem Express

EGFR-IN-42 [3031307-73-7]

10

Research Use Only

C49H53ClFN5O5

846.43

EGFR-IN-42 (Compound 17b) is a potent inhibitor of EGFR with single-digit nanomolar activity. EGFR-IN-42 connects tamoxifen or endoxifen with the EGFR-inhibitor gefitinib via a covalent linkage. EGFR-IN-42 retains both ER antagonist activity and EGFR inhibition. EGFR-IN-42 has superior anti-cancer activity[1].

ClC1=CC(NC2=C3C(C=C(OC)C(OCCCNC(CCCCCN(CCOC4=CC=C(C=C4)/C(C5=CC=C(C=C5)O)=C(CC)\C6=CC=CC=C6)C)=O)=C3)=NC=N2)=CC=C1F

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