EGFR-IN-50 [2044508-48-5]

MedChem Express

EGFR-IN-50 [2044508-48-5]

10

2044508-48-5

Research Use Only

C24H26BrN3O4S2

564.51

EGFR-IN-50 (Compound 9h) is a potent EGFR inhibitor against L858R resistance mutation (TEL-EGFR-L858R-BaF3: GI50=8 nM, TEL-EGFR-T790M-L858R-BaF3: GI50=6.03 microM). EGFR-IN-50 shows anti-proliferative activity to cancer cells[1].

C=CCSSCCC(OCCCOC1=CC2=C(C(NC3=CC(Br)=CC=C3)=NC=N2)C=C1OC)=O

12131703