EGFR-IN-60 [2699877-43-3]
HY-147826
CAS Number2699877-43-3
Product group Chemicals
Molecular Weight535.47
Overview
- SupplierMedChem Express
- Product NameEGFR-IN-60 [2699877-43-3]
- Delivery Days Customer10
- CAS Number2699877-43-3
- CertificationResearch Use Only
- Molecular FormulaC28H28Cl2N6O
- Molecular Weight535.47
- Scientific DescriptionEGFR-IN-60 (Compound 7d) shows obvious inhibition of EGFRWT, EGFRT790M, EGFRL858R and JAK3 with IC50s of 83, 26, 53, and 69 nM, respectively. EGFR-IN-60 potently inhibits the growth of H1975 cells harboring EGFRT790M mutation (IC50=1.32 microM) over A431 cells overexpressing EGFRWT (IC50=4.96 microM). EGFR-IN-60 exhibits good oral absorption, potent and safe antitumor activity. EGFR-IN-60 induces cell death through apoptosis supported by increased Bax/Bcl-2 ratio[1].
- SMILESO=C1C2=C(NC(N=CN(/N=C/C3=CC=C(N(C)C)C=C3)C4=N)=C4C2C5=CC=CC(Cl)=C5Cl)CC(C)(C)C1
- UNSPSC12131703