Bio-Connect

EGFR-IN-61 [2890261-81-9]

HY-147860
MedChem Express
CAS Number2890261-81-9
Product group Chemicals
Molecular Weight629.15
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Overview

  • Supplier
    MedChem Express
  • Product Name
    EGFR-IN-61 [2890261-81-9]
  • Delivery Days Customer
    10
  • CAS Number
    2890261-81-9
  • Certification
    Research Use Only
  • Molecular Formula
    C33H37ClN8O3
  • Molecular Weight
    629.15
  • Scientific Description
    EGFR-IN-61 (compound 22a) is a potent EGFR kinase inhibitor, with IC50 values of 42 nM (L858R/T790 M), 137 nM (L858R/T790 M/C797S), and 743 nM (WT), respectively. EGFR-IN-61 shows antiproliferative activity against A549 and H1975 cell lines, with IC50 values of 2.14 and 1.82 microM, respectively[1].
  • SMILES
    COC1=CC(N(CCN(C)C)C)=C(C=C1NC2=NC(C3=CN(C4=C3C=CC=C4)CCCO)=CC=N2)NC(C5=CC(Cl)=NC=C5)=O
  • UNSPSC
    12131703