EGFR-IN-61 [2890261-81-9]
HY-147860
Overview
- SupplierMedChem Express
- Product NameEGFR-IN-61 [2890261-81-9]
- Delivery Days Customer10
- CAS Number2890261-81-9
- CertificationResearch Use Only
- Molecular FormulaC33H37ClN8O3
- Molecular Weight629.15
- Scientific DescriptionEGFR-IN-61 (compound 22a) is a potent EGFR kinase inhibitor, with IC50 values of 42 nM (L858R/T790 M), 137 nM (L858R/T790 M/C797S), and 743 nM (WT), respectively. EGFR-IN-61 shows antiproliferative activity against A549 and H1975 cell lines, with IC50 values of 2.14 and 1.82 microM, respectively[1].
- SMILESCOC1=CC(N(CCN(C)C)C)=C(C=C1NC2=NC(C3=CN(C4=C3C=CC=C4)CCCO)=CC=N2)NC(C5=CC(Cl)=NC=C5)=O
- UNSPSC12131703