EGFR-IN-82 [2568086-81-5]
HY-149401
Overview
- SupplierMedChem Express
- Product NameEGFR-IN-82 [2568086-81-5]
- Delivery Days Customer14
- CAS Number2568086-81-5
- CertificationResearch Use Only
- Molecular FormulaC32H41BrN9O2P
- Molecular Weight694.60
- Scientific DescriptionEGFR-IN-82 (Cmpound 8a) is a potent and orally active EGFR inhibitor with IC50 values of 0.09 and 0.06 nM for EGFRL858R/T790M/C797S and EGFRDel19/T790M/C797S, respectively. EGFR-IN-82 has no significant effect on EGFRWT. EGFR-IN-82 has anti-proliferative activity and inhibits tumor formation in nude mice. EGFR-IN-82 can be used in non-small cell lung cancer research [1].
- SMILESCOC1=C(NC2=NC=C(Br)C(NC3=C(P(C)(C)=O)C(N=CC=N4)=C4C=C3)=N2)C=C(C)C(N5CCC(N6CC(N(C)C)C6)CC5)=C1
- UNSPSC12131703