Bio-Connect

EGFR-IN-82 [2568086-81-5]

HY-149401
MedChem Express
CAS Number2568086-81-5
Product group Chemicals
Molecular Weight694.60
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Overview

  • Supplier
    MedChem Express
  • Product Name
    EGFR-IN-82 [2568086-81-5]
  • Delivery Days Customer
    14
  • CAS Number
    2568086-81-5
  • Certification
    Research Use Only
  • Molecular Formula
    C32H41BrN9O2P
  • Molecular Weight
    694.60
  • Scientific Description
    EGFR-IN-82 (Cmpound 8a) is a potent and orally active EGFR inhibitor with IC50 values of 0.09 and 0.06 nM for EGFRL858R/T790M/C797S and EGFRDel19/T790M/C797S, respectively. EGFR-IN-82 has no significant effect on EGFRWT. EGFR-IN-82 has anti-proliferative activity and inhibits tumor formation in nude mice. EGFR-IN-82 can be used in non-small cell lung cancer research [1].
  • SMILES
    COC1=C(NC2=NC=C(Br)C(NC3=C(P(C)(C)=O)C(N=CC=N4)=C4C=C3)=N2)C=C(C)C(N5CCC(N6CC(N(C)C)C6)CC5)=C1
  • UNSPSC
    12131703