EGFR/c-Met-IN-1

MedChem Express

EGFR/c-Met-IN-1

14

Research Use Only

C30H25FN6O5

568.56

EGFR/c-Met-IN-1 (compound TS-41) is a dual-target inhibitor of EGFR/c-Met. The IC50 for inhibiting EGFRL858R and c-Met is 68.1 nM and 0.26 nM respectively. . EGFR/c-Met-IN-1 induces apoptosis and cell cycle arrest in A549-P cells, downregulating the phosphorylation of EGFR, c-Met, and downstream AKT. EGFR/c-Met-IN-1 inhibits tumor growth in vitro and in vivo[1].

O=C(C1=C(C)N(C)N(C2=CC=CC=C2)C1=O)NC3=CC=C(OC4=C5C=C(NC(C=C)=O)C(OC)=CC5=NC=N4)C(F)=C3

12352200