EGFR/DHFR-IN-2

MedChem Express

EGFR/DHFR-IN-2

5

Research Use Only

C24H16N4O5

440.41

EGFR/DHFR-IN-2 (9b) is a dual h-DHFR/EGFRTK inhibitor, with IC50 values of 0.192 microM and 0.109 microM for h-DHFR and EGFR, respectively. EGFR/DHFR-IN-2 (9b) halts the cell cycle at the G1/S phase and induces apoptosis. EGFR/DHFR-IN-2 (9b) is a potential inhibitor of CYP2C9 and CYP3A4. EGFR/DHFR-IN-2 (9b) can be used in the cancer research[1].

CCOC(C1=CC=C(C=C1)N2C(N)=C(C3(C(C#N)=C2O)C(C4=CC=CC=C4C3=O)=O)C#N)=O

12352200