EGFR/HER2-IN-8

MedChem Express

EGFR/HER2-IN-8 [2820126-32-5]

10

Research Use Only

C16H16N4O2S

328.39

EGFR/HER2-IN-8 (compound 34) is a EGFR/HER2 and DHFR inhibitor. EGFR/HER2-IN-8 inhibits EGFR kinase, HER2 kinase and DHFR with IC50s of 0.45, 0.244 and 5.669 microM, respectively. EGFR/HER2-IN-8 shows anticancer activity against several cancer cell lines with high safety profile and selectivity indices. EGFR/HER2-IN-8 can be used for the research of cancer[1].

O=C(C1=CSC2=NC=C(C3=CC=C(C)C=C3)N21)NNC(CC)=O

12131703