EGFR/HER2/DHFR-IN-2

MedChem Express

EGFR/HER2/DHFR-IN-2

14

Research Use Only

C22H19BrN2O

407.30

EGFR/HER2/DHFR-IN-2 (Compound 4b) is an inhibitor of EGFR, HER2, and DHFR (IC50: 0.248, 0.156, 0.138 microM respectively). EGFR/HER2/DHFR-IN-2 has anticancer activities against a panel of cancer cells (IC50: 9.14, 7.33, 14.18, 24.87, 20.07, 6.16 microM for Hep G2, HeLa, HEp-2, HCT 116, PC-3, MCF7 cells). EGFR/HER2/DHFR-IN-2 reduce breast cancer tumor growth[1].

N#CC1=C(OCCC)N=C(C2=CC=C(C)C=C2)C=C1C3=CC=C(Br)C=C3

12352200