EGFR/HER2/DHFR-IN-3

MedChem Express

EGFR/HER2/DHFR-IN-3

14

Research Use Only

C22H19N3O3

373.40

EGFR/HER2/DHFR-IN-3 (compound 4c) is a potent dual inhibitor of EGFR/HER2, with IC50s of 0.138 and 0.092 microM, respectively. EGFR/HER2/DHFR-IN-3 also inhibits DHFR, with an IC50 of 0.193 M. EGFR/HER2/DHFR-IN-3 causes arrest at the S phase of the cell cycle and induces apoptosis in MCF7 breast cancer cells[1].

N#CC1=C(OCCC)N=C(C2=CC=C(C)C=C2)C=C1C3=CC=C([N+]([O-])=O)C=C3

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