EGFR/microtubule-IN-1 [1970269-96-5]

TargetMol Chemicals

EGFR/microtubule-IN-1 [1970269-96-5]

16

Research Use Only

C23H18BrN5O3

492.32

EGFR/microtubule-IN-1 (Compound 10c) functions as a dual inhibitor of both EGFR and tubulin, displaying an IC 50 of 10.66 nM against EGFR. It effectively reduces the phosphorylation levels of EGFR, AKT, and ERK, impedes tubulin polymerization, and induces apoptosis [1].

N(C=1C2=C(C=C(OC)C(NC(NC(=O)C3=CC=CC=C3)=O)=C2)N=CN1)C4=CC=C(Br)C=C4

-20°C

51202000