EHMT1 (C) Antibody, Rabbit Polyclonal

Biorbyt

EHMT1 (C) Antibody, Rabbit Polyclonal

16

Western Blot

WB:1:1000-1:5000 WB

Research Use Only

Polyclonal

Unconjugated

EHMT1

euchromatic histone lysine methyltransferase 1

EHMT1-IT1, EUHMTASE1, Eu-HMTase1, FP13812, GLP, GLP1, KLEFS1, KMT1D, histone-lysine N-methyltransferase EHMT1, EHMT1 intronic transcript 1, G9a-like protein 1, H3-K9-HMTase 5, euchromatic histone-lysine N-methyltransferase 1, histone H3-K9 methyltransferase 5, histone-lysine N-methyltransferase, H3 lysine-9 specific 5, lysine N-methyltransferase 1D

Rabbit

Histone-lysine N-methyltransferase EHMT1

Rabbit polyclonal to EHMT1.EHMT1 is a Histone-lysine N-methyltransferase that specifically mono-and dimethylates Lys-9 ofhistone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tagfor epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. EHMT1also weakly methylates Lys-27 of histone H3 (H3K27me). EHMTa is also required for DNAmethylation independent of its histone methyltransferase. During G0 phase, EHMT1 contributes tosilencing of MYC-and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. Inaddition to the histone methyltransferase activity, EHMT1 also methylates non-histone proteins, suchas the dimethylation of Lys-373 of p53/TP53.

Human

-20°C

12352203