Bio-Connect

eIF4A3-IN-1

HY-101513
MedChem Express
CAS Number2095486-67-0
Product group Chemicals
Estimated Purity99.96
Molecular Weight588.88
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Overview

  • Supplier
    MedChem Express
  • Product Name
    eIF4A3-IN-1 [2095486-67-0]
  • Delivery Days Customer
    9
  • CAS Number
    2095486-67-0
  • Certification
    Research Use Only
  • Estimated Purity
    99.96
  • Molecular Formula
    C29H23BrClN5O2
  • Molecular Weight
    588.88
  • Scientific Description
    eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor ( IC 50 =0.26 microM; K d =0.043 microM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 microM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD [1] .
  • SMILES
    ClC(C=C1)=CC=C1[C@@H]2N(C(C3=CC=C(Br)C=C3)=O)CCN(C(C4=C(C)N(C5=CC=CC(C#N)=C5)N=C4)=O)C2
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200