eIF4A3-IN-1
HY-101513
CAS Number2095486-67-0
Product group Chemicals
Estimated Purity99.96
Molecular Weight588.88
Overview
- SupplierMedChem Express
- Product NameeIF4A3-IN-1 [2095486-67-0]
- Delivery Days Customer9
- CAS Number2095486-67-0
- CertificationResearch Use Only
- Estimated Purity99.96
- Molecular FormulaC29H23BrClN5O2
- Molecular Weight588.88
- Scientific DescriptioneIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor ( IC 50 =0.26 microM; K d =0.043 microM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 microM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD [1] .
- SMILESClC(C=C1)=CC=C1[C@@H]2N(C(C3=CC=C(Br)C=C3)=O)CCN(C(C4=C(C)N(C5=CC=CC(C#N)=C5)N=C4)=O)C2
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200