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Western blot analysis of extracts from HepG2 and HT29 cells using eIF4G(Ab-1232) Antibody.
Western blot analysis of extracts from HepG2 and HT29 cells using eIF4G(Ab-1232) Antibody.
Western blot analysis of extracts from HepG2 and HT29 cells using eIF4G(Ab-1232) Antibody.

EIF4G1 (Ab-1232) Antibody

Research Use Only
CSB-PA061737
Cusabio
ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetEIF4G1
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More than 130 suppliers
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Overview

  • Supplier
    Cusabio
  • Product Name
    EIF4G1 (Ab-1232) Antibody
  • Delivery Days Customer
    20
  • Applications
    ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID1981
  • Target name
    EIF4G1
  • Target description
    eukaryotic translation initiation factor 4 gamma 1
  • Target synonyms
    EIF4F; EIF4G; EIF-4G1; EIF4-gamma; eIF-4-gamma 1; EIF4GI; eucaryotic translation initiation factor 4G; eukaryotic translation initiation factor 4 gamma 1; P220; PARK18
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ04637
  • Protein Name
    Eukaryotic translation initiation factor 4 gamma 1
  • Scientific Description
    eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3. Interacts with MIF4GD. Interacts with rotavirus A NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis De Gregorio, E. et al. (1998) RNA 4, 828-836. Ohlmann, T. et al. (1996) EMBO J. 15, 1371-1382. Borman, A.M. and Kean, K.M. (1997) Virology 237, 129-136. Gradi, A. et al. (1998) Mol Cell Biol 18, 334-42.
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203