Elezanumab [1791416-49-3]
HY-P99359
Product group Antibodies
Overview
- SupplierMedChem Express
- Product NameElezanumab [1791416-49-3]
- Delivery Days Customer10
- CAS Number1791416-49-3
- CertificationResearch Use Only
- ClonalityMonoclonal
- Estimated Purity99.91
- Scientific DescriptionElezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC50 around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism[1][2].
- Storage Instruction-80°C
- UNSPSC41116161