Elobixibat [439087-18-0] [439087-18-0]

Chemodex

Elobixibat [439087-18-0] [439087-18-0]

10

439087-18-0

Research Use Only

>98%

Warning

C36H45N3O7S2

695.89

Chemical. CAS: 439087-18-0. Formula: C36H45N3O7S2. MW: 695.89. Elobixibat is an inhibitor of the sodium/bile acid and sulfated solute cotransporter (ASBT), also known as the ileal bile acid transporter (IBAT) which is selective for ASBT over the hepatic sodium/bile acid cotransporter. Oral administration of elobixibat reduces methionine- and choline-deficient diet-induced increases in serum bile acid levels and hepatic inflammation, fibrosis, and cytokine gene expression in a mouse model of non-alcoholic steatohepatitis (NASH). Elobixibat lowers LDL cholesterol, increases serum GLP-1, promotes colon motility, and has the potential to treat metabolic syndrome. Elobixibat can be used to study constipation, dyslipidemia, non-alcoholic hepatitis and liver tumors. - Elobixibat is an inhibitor of the sodium/bile acid and sulfated solute cotransporter (ASBT), also known as the ileal bile acid transporter (IBAT) which is selective for ASBT over the hepatic sodium/bile acid cotransporter. Oral administration of elobixibat reduces methionine- and choline-deficient diet-induced increases in serum bile acid levels and hepatic inflammation, fibrosis, and cytokine gene expression in a mouse model of non-alcoholic steatohepatitis (NASH). Elobixibat lowers LDL cholesterol, increases serum GLP-1, promotes colon motility, and has the potential to treat metabolic syndrome. Elobixibat can be used to study constipation, dyslipidemia, non-alcoholic hepatitis and liver tumors.

O=S1(=O)C=2C(N(CC(CCCC)(CCCC)C1)C3=CC=CC=C3)=CC(SC)=C(OCC(N[C@@H](C(NCC(O)=O)=O)C4=CC=CC=C4)=O)C2

-20°C,2°C to 8°C

12352200