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ProductsBack/EM127 [1886879-71-5]

EM127 [1886879-71-5]

HY-151379
MedChem Express
CAS Number1886879-71-5
DownloadMSDS
Product group Chemicals
Estimated Purity99.94
Molecular Weight311.76
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Overview

  • Supplier
    MedChem Express
  • Product Name
    EM127 [1886879-71-5]
  • Delivery Days Customer
    10
  • CAS Number
    1886879-71-5
  • Certification
    Research Use Only
  • Estimated Purity
    99.94
  • Molecular Formula
    C14H18ClN3O3
  • Molecular Weight
    311.76
  • Scientific Description
    EM127 (compound 11c) is a SMYD3 covalent inhibitor with high selectivity, high affinity (KD=13 microM) and site-specificity. EM127 effectively inhibits ERK1/2 phosphorylation and reduces transcriptional regulation of SMYD3 target genes. EM127 effectively and prolongedly impairs methyltransferase activity. EM127 can be used in cancer research, particularly in SMYD3 positive tumours[1].
  • SMILES
    O=C(C1=NOC(C2CC2)=C1)NC3CCN(C(CCl)=O)CC3
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12131703