Emrusolmin

MedChem Express

Emrusolmin [882697-00-9]

10

882697-00-9

99.93

C16H11BrN2O2

343.17

Emrusolmin (Anle138b), an oligomeric aggregation inhibitor, blocks the formation of pathological aggregates of prion protein (PrPSc) and of alpha-synuclein (alpha-syn). Emrusolmin strongly inhibits oligomer accumulation, neuronal degeneration, and disease progression in vivo. Emrusolmin has low toxicity and an excellent oral bioavailability and blood-brain-barrier penetration. Emrusolmin blocks Abeta channels and rescues disease phenotypes in a mouse model for amyloid pathology [1] [2] .

BrC1=CC(C2=CC(C3=CC=C(OCO4)C4=C3)=NN2)=CC=C1

-20°C,2°C to 8°C

12352200