EN6

MedChem Express

EN6 [1808714-73-9]

10

1808714-73-9

Research Use Only

99.42

C19H14F2N4O2

368.34

EN6 is a small-molecule in vivo autophagy activator that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase . EN6-mediated modification of ATP6V1A uncouples v-ATPase from Rag , leading to inhibition of mTORC1 signalling, increased lysosomal acidification, and activation of autophagy. EN6 also scavenges TDP-43 aggregates (causative agents of frontotemporal dementia) in a lysosome-dependent manner [1] .

O=C(C1=CN(C2=CC=CC=C2F)N=C1)NC3=CC=C(F)C(NC(C=C)=O)=C3

-20°C,2°C to 8°C

12352200