ENaC Beta Antibody (OASE00461)

Aviva Systems Biology

ENaC Beta Antibody (OASE00461)

23

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

Liquid PBS with 0.09% sodium azide and 50% glycerol

Scnn1b

sodium channel epithelial 1 subunit beta

RNENACB, epithelial sodium channel subunit beta, amiloride-sensitive sodium channel subunit beta, SCNEB, beta-ENaC, beta-NaCH, epithelial Na(+) channel subunit beta, nonvoltage-gated sodium channel 1 subunit beta, sodium channel epithelial 1 beta subunit, sodium channel, non-voltage-gated 1, beta subunit, sodium channel, nonvoltage-gated, type I, beta

Rabbit

The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na+-ion transport (1). Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption (2). ENaCs are composed of three structurally related subunits that form a tetrameric channel, I+/-, beta, and I3. The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate (3, 4). The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal lung epithelia(5). And it has been concluded that the subunits are differentially expressed in the retina of mice with ocular hypertension, therefore the up-regulation of alpha-ENaC proteins could serve as a protection mechanism against elevated intraocular pressure (6).

-20°C

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