Enavatuzumab [1062149-33-0]
HY-P99361
Product group Antibodies
Overview
- SupplierMedChem Express
- Product NameEnavatuzumab [1062149-33-0]
- Delivery Days Customer10
- CAS Number1062149-33-0
- CertificationResearch Use Only
- ClonalityMonoclonal
- Estimated Purity99.0
- Scientific DescriptionEnavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo [1] [2].
- Storage Instruction-80°C
- UNSPSC41116161