Endosidin-2 [1839524-44-5]

MedChem Express

Endosidin-2 [1839524-44-5]

10

1839524-44-5

Research Use Only

99.17

C15H12FIN2O3

414.17

Endosidin-2 (ES2) is a selective inhibitor targeting the conserved exosome subunit EXO70. Endosidin-2 binds to the C-terminal domain of EXO70, inhibiting exocytosis and endosomal recycling, while promoting vacuolar trafficking in plant cells. Endosidin-2 interferes with the EXO70-mediated vesicle-to-plasma membrane anchoring process, leading to abnormal aggregation of auxin transporters (such as PIN2) in the cytoplasm and redirected to vacuolar degradation, while causing abnormal Golgi structure (such as cup-shaped or ring-shaped vesicles cisternae formation). Endosidin-2 can inhibit exocytosis in plant and mammalian cells and is mainly used to study the dynamic regulation of membrane trafficking (such as polar growth, vesicle sorting)[1][2].

O=C(N/N=C/C1=CC(OC)=C(O)C(I)=C1)C2=CC=CC(F)=C2

-20°C,2°C to 8°C

12352200