(+/-)-Enitociclib
HY-103019A
CAS Number1610358-53-6
Product group Chemicals
Estimated Purity99.87
Molecular Weight404.43
Overview
- SupplierMedChem Express
- Product Name(+/-)-Enitociclib [1610358-53-6]
- Delivery Days Customer10
- CAS Number1610358-53-6
- CertificationResearch Use Only
- Estimated Purity99.87
- Molecular FormulaC19H18F2N4O2S
- Molecular Weight404.43
- Scientific Description(+/-)-Enitociclib ((+/-)-BAY-1251152) is the racemic mixture of Enitociclib (HY-103019E). Enitociclib is a selective CDK9 inhibitor and apoptosis inducer. Enitociclib inhibits CDK9 activity and reduces the phosphorylation of Ser2 in the carboxyl-terminal domain (CTD) of RNA polymerase Pol II, thereby downregulating the transcription of key oncogenes such as MYC and MCL1. Enitociclib has anti-proliferative activity targeting MYC+ lymphoma and multiple myeloma (MM) cells, and has synergistic effects with Bortezomib (HY-10227) and Lenalidomide (HY-A0003), and can be used in the research of hematological malignancies[1][2].
- SMILESN=S(CC1=CC(NC2=NC=C(F)C(C3=CC=C(F)C=C3OC)=C2)=NC=C1)(C)=O
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200