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(+/-)-Enitociclib

HY-103019A
MedChem Express
CAS Number1610358-53-6
Product group Chemicals
Estimated Purity99.87
Molecular Weight404.43
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Overview

  • Supplier
    MedChem Express
  • Product Name
    (+/-)-Enitociclib [1610358-53-6]
  • Delivery Days Customer
    10
  • CAS Number
    1610358-53-6
  • Certification
    Research Use Only
  • Estimated Purity
    99.87
  • Molecular Formula
    C19H18F2N4O2S
  • Molecular Weight
    404.43
  • Scientific Description
    (+/-)-Enitociclib ((+/-)-BAY-1251152) is the racemic mixture of Enitociclib (HY-103019E). Enitociclib is a selective CDK9 inhibitor and apoptosis inducer. Enitociclib inhibits CDK9 activity and reduces the phosphorylation of Ser2 in the carboxyl-terminal domain (CTD) of RNA polymerase Pol II, thereby downregulating the transcription of key oncogenes such as MYC and MCL1. Enitociclib has anti-proliferative activity targeting MYC+ lymphoma and multiple myeloma (MM) cells, and has synergistic effects with Bortezomib (HY-10227) and Lenalidomide (HY-A0003), and can be used in the research of hematological malignancies[1][2].
  • SMILES
    N=S(CC1=CC(NC2=NC=C(F)C(C3=CC=C(F)C=C3OC)=C2)=NC=C1)(C)=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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