Enpatoran

MedChem Express

Enpatoran [2101938-42-3]

5

2101938-42-3

Research Use Only

99.80

C16H15F3N4

320.31

Enpatoran (M5049) is a potent, orally active and dual TLR7/8 inhibitor with IC 50 s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran is inactive against TLR3, TLR4 and TLR9. Enpatoran can block molecule synthetic ligands and natural endogenous RNA ligands. Enpatoran exhibits excellent pharmacokinetic properties in vivo . Enpatoran can be used for both innate and adaptive autoimmunity blocking research [1] .

N#CC(C=C1)=C(N=CC=C2)C2=C1N3C[C@@H](C(F)(F)F)C[C@@H](N)C3

-20°C

12352200