Entacapone

MedChem Express

Entacapone [130929-57-6]

10

130929-57-6

Research Use Only

99.97

C14H15N3O5

305.29

Entacapone is a potent, reversible, peripherally acting and orally active catechol-O-methyltransferase (COMT) inhibitor. Entacapone inhibits COMT from rat brain, erythrocytes and liver with IC 50 values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone is selective for COMT over other catecholamine metabolizing enzymes, including MAO-A, MAO-B, phenolsulphotransferase M (PST-M) and PST-P (IC 50 s>50 microM). Entacapone can be used for the research of Parkinsons disease [1] . Entacapone serves as a inhibitor of FTO demethylation with an IC 50 of 3.5 microM, can be used for the research of metabolic disorders [2] .

O=C(N(CC)CC)/C(C#N)=C/C1=CC([N+]([O-])=O)=C(O)C(O)=C1

-20°C,2°C to 8°C

12352200