Eotaxin 2 antibody [61016.11]

GeneTex

Eotaxin 2 antibody [61016.11]

9

WB: 1-2 microg/ml. ELISA: 2 microg/ml. Neutralizing/Inhibition: 1-5 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

61016.11

Unconjugated

CCL24

C-C motif chemokine ligand 24

C-C motif chemokine 24; chemokine (C-C motif) ligand 24; Ckb-6; CK-beta-6; eosinophil chemotactic protein 2; eotaxin-2; MPIF2; MPIF-2; myeloid progenitor inhibitory factor 2; SCYA24; small inducible cytokine subfamily A (Cys-Cys), member 24; small-inducible cytokine A24

Mouse

IgG1

C-C motif chemokine 24

Eotaxin 2, also named MPIF2, Ckbeta6, and SCYA24, is a member of the CC chemokine family, based on the presence of the CC motif and homology with other known CC chemokines. Eotaxin 2 cDNA encodes a 119 amino acid residue precursor protein with a 26 amino acid residue signal peptide that is cleaved to generate a mature protein predicted to contain 93 amino acid residues with an N glycosylation site. Mature human eotaxin 2 has a predicted molecular mass of approximately 10.6 kDa. Compared to other CC chemokines, eotaxin 2 exhibits 40 %, 42 %, and 39 % amino acid identity to MCP3, MIP1 alpha, and eotaxin, respectively. Human CC chemokine eotaxin 2 maps to chromosome 7q11.23. Both eotaxin and eotaxin 2 activate and attract eosinophils and basophils. A receptor for human eotaxin has been identified and found to be the third numbered receptor in the C-C chemokine subfamily of receptors (CCR3. On eosinophils, the effects of eotaxin 2 is inhibited by an CCR3 antibody and cross-desensitized by eotaxin and MCP4, suggesting that all three CC chemokines act through CCR3. Eotaxin 2 mRNA is weakly expressed in activated monocytes and T lymphocytes. Recombinant eotaxin 2 induces chemotaxis of eosinophils, basophils, and resting T lymphocytes but not monocytes and activated T lymphocytes. Eotaxin 2 inhibits colony formation in myleloid progenitor cells.

Human

-20°C or -80°C,2°C to 8°C

12352203