EP4 receptor antagonist 7 [3035217-40-1]

MedChem Express

EP4 receptor antagonist 7 [3035217-40-1]

5

Research Use Only

453.41

EP4 receptor antagonist 7 (Compound 14) is an antagonist of the prostaglandin E2 ( PGE2 ) receptor subtype EP4 with an IC 50 value of 1.1 nM. EP4 receptor antagonist 7 inhibits PGE2-induced beta-arrestin recruitment in HEK293 cells with an IC 50 value of 0.9 nM. EP4 receptor antagonist 7 decreases PGE2-induced expression of mRNA encoding IL-4, macrophage mannose receptor 1 (Mrc1), chitinase-like protein 3 (Chil3), chemokine (C-X-C) motif ligand 1 (Cxcl1), triggering receptor expressed on myeloid cells 2 (Trem2), and arginase-1 (Arg1), in RAW 264.7 macrophages. EP4 receptor antagonist 7 combined with an anti-PD-1 antibody inhibits tumor growth and increases infiltration of CD 8+ T cells into tumors in a CT26 murine colon cancer model [1] .

O=C(C1=CC=C(CNC(C2=C3C=CC=CC3=NN2CC4=CC=C(C(F)(F)F)C=C4)=O)C=C1)O

12352005