Epacadostat [1204669-58-8]

MedChem Express

Epacadostat [1204669-58-8]

10

1204669-58-8

Research Use Only

99.65

h302, h315, h319, h335

C11H13BrFN7O4S

438.23

Epacadostat (INCB 024360) is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1) inhibitor with an IC50 of 71.8 nM[1]. Epacadostat can effectively reduce Trp metabolism, entailing increased activation and maturation of dendritic cells, and enhanced proliferation of effector T cells and natural killer cells (NKs), as well as attenuated Tregs expansion.

BrC1=C(F)C=CC(N/C(C2=NON=C2NCCNS(N)(=O)=O)=N\O)=C1

-20°C,2°C to 8°C

12352200