EphB4 antibody

GeneTex

EphB4 antibody

9

WB: 0.1-0.2 microg/ml. IHC: 5-15 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Dot Blot, Flow Cytometry, Western Blot, ELISA, ImmunoHistoChemistry, Neutralisation/Blocking

Research Use Only

Polyclonal

Unconjugated

Ephb4

Eph receptor B4

AI042935; b2b2412C; b2b2412Clo; developmental kinase 2; ephrin type-B receptor 4; hepatoma transmembrane kinase; Htk; MDK2; mDK-2; Myk1; Tyro; Tyro11; tyrosine kinase MYK-1

Goat

IgG

Ephrin type-B receptor 4

EphB4, also known as Htk, Myk1, Tyro11, and Mdk2, is a member of the Eph receptor family, which binds of the ephrin ligand family. Two classes of receptors exist, designated A and B, that have an extracellular domain made up of a globular domain, a cysteine-rich domain, and two fibronectin type III domains, followed by the transmembrane region and cytoplasmic region. The cytoplasmic region contains juxtamembrane motif with two tyrosines, which are the major autophosphorylation sites, along with a kinase domain, and a conserved sterile alpha motif (SAM) in the carboxyl terminus, which includes one conserved tyrosine. Ligand recognition and binding leads to activation of intrinsic kinase activity. Only membrane-bound or Fc-clustered ligands have been shown to activate the receptor in vitro. Soluble monomeric ligands can bind the receptor, but do not induce receptor autophosphorylation and activation. The Eph receptors and ephrin ligands display reciprocal expression in vivo. Developing and adult neural tissue express nearly all of the Eph receptors and ephrin ligands.Ephs and ephrins play a significant role in angiogenesis.

Mouse

-20°C or -80°C,2°C to 8°C

12352203