Epiberberine [6873-09-2]

MedChem Express

Epiberberine [6873-09-2]

10

6873-09-2

Research Use Only

98.46

C20H18NO4+

336.36

Epiberberine is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 microM, respectively. Epiberberine has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 microM), and can be used for the research of Alzheimer disease[1]. Epiberberine inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKalpha/Akt pathways[2]. Epiberberinecan be used for the research of diabetic disease[3].

COC1=C(OC)C=C2C(CC[N+]3=C2C=C(C=C4)C(C5=C4OCO5)=C3)=C1

-20°C,2°C to 8°C

12352200