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Immunohistochemistry of paraffin-embedded human salivary gland tissue using CSB-PA007738ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human salivary gland tissue using CSB-PA007738ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human salivary gland tissue using CSB-PA007738ESR1HU at dilution of 1:100

EPM2A Antibody

CSB-PA007738ESR1HU
Cusabio
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetEPM2A
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Overview

  • Supplier
    Cusabio
  • Product Name
    EPM2A Antibody
  • Delivery Days Customer
    20
  • Applications
    ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID7957
  • Target name
    EPM2A
  • Target description
    EPM2A glucan phosphatase, laforin
  • Target synonyms
    epilepsy, progressive myoclonus type 2, Lafora disease (laforin); epilepsy, progressive myoclonus type 2A, Lafora disease (laforin); EPM2; EPM2A, laforin glucan phosphatase; glucan phosphatase; glycogen phosphatase; lafora PTPase; laforin; LAFPTPase; MELF
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO95278
  • Protein Name
    Laforin
  • Scientific Description
    Has both dual-specificity protein phosphatase and glucan phosphatase activities. Together with the E3 ubiquitin ligase NHLRC1/malin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. Dephosphorylates phosphotyrosine, phosphoserine and phosphothreonine substrates in vitro. Has also been shown to dephosphorylate MAPT. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates. Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Also promotes proteasome-independent protein degradation through the macroautophagy pathway. Isoform 2, an inactive phosphatase, could function as a dominant-negative regulator for the phosphatase activity of isoform 1.
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    41116161

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