(+/-)-Equol [94105-90-5]

TargetMol Chemicals

(+/-)-Equol [94105-90-5]

4

94105-90-5

Chemical

Research Use Only

(±)-Equol

98.28%

C15H14O3

242.27

(+/-)-Equol ((R,S)-Equol) is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (ER) agonist activity of the naturally occurring (S)-enantiomer (EC50 = 85 and 65 nM for human ERalpha and ERbeta, respectively) is similar to that of genistein but exceeds that of daidzein. (+/-)-Equol preferentially binds ERbeta (Ki = 0.73 nM) and demonstrates approximately 9-fold lower affinity for ERalpha (Ki = 6.41 nM). (+/-)-Equol is also a potent antagonist of dihydrotestosterone, which has important implications for prostate cancer and other androgen-mediated pathologies.

3 years

OC=1C=C2C(CC(CO2)C3=CC=C(O)C=C3)=CC1

-20°C

12352200