Erastin

MedChem Express

Erastin [571203-78-6]

10

571203-78-6

Research Use Only

99.76

C30H31ClN4O4

547.04

Erastin is a ferroptosis inducer. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels ( VDAC2/VDAC3 ) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity. Furthermore, Erastin can block the uptake of cystine mediated by SLC7A11 and also spares UMRC6-EV and -C91A cells from disulfidptosis under glucose starvation [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] .

O=C1N(C2=CC=CC=C2OCC)C(C(N3CCN(C(COC4=CC=C(Cl)C=C4)=O)CC3)C)=NC5=C1C=CC=C5

-20°C,2°C to 8°C

12352200