Erastin2 [1695533-44-8]
T35994
Overview
- SupplierTargetMol Chemicals
- Product NameErastin2 [1695533-44-8]
- Delivery Days Customer10
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameErastin2
- Estimated Purity99.63%
- Molecular FormulaC36H35ClN4O4
- Molecular Weight623.14
- Scientific DescriptionErastin2 is a ferroptosis inducer and inhibitor of the system xc- cystine/glutamate transporter.[1][2] It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 µM) and induces cell death in HAP1 cells at 5 µM, an effect blocked by ferrostatin-1 or deferoxamine.[1][2] Erastin2 also induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 µM), an effect blocked by beta-mercaptoethanol (EC50 > 20 µM).[3] Additionally, it increases lipid peroxidation in HT-1080 cells at 1 µM.
- Shelf life instruction3 years
- SMILESCC(C)Oc1ccc(cc1-n1c(CN2CCN(CC2)C(=O)COc2ccc(Cl)cc2)nc2ccccc2c1=O)-c1ccccc1
- Storage Instruction-20°C
- UNSPSC12352200
