ERBB agonist-1
HY-168438
Estimated Purity99.16
Product group Chemicals
Molecular Weight419.54
Overview
- SupplierMedChem Express
- Product NameERBB agonist-1
- Delivery Days Customer5
- CertificationResearch Use Only
- Estimated Purity99.16
- Molecular FormulaC24H25N3O2S
- Molecular Weight419.54
- Scientific DescriptionERBB agonist-1 (Compound EF-1) is an agonist for ERBB4, that activates the ERBB4 signaling pathway by inducing dimerization of the ERBB4 receptor with an EC50 of 10.5 microM. ERBB agonist-1 induces phosphorylation of Akt and ERK1/2, reduces the collagen expression in cardiac fibroblasts, inhibits H2O2-induced cardiomyocyte death and Ang II (HY-13948)-induced cardiomyocyte hypertrophy. ERBB agonist-1 prevents fibrosis and exhibits cardioprotective efficacy in mouse models[1].
- SMILESO=C(NC1CC1)C(SC(N2C3CCCC3)=NC4=CC=CC=C4C2=O)C5=CC=CC=C5
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200