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ERG blocking peptide

Research Use Only
GTX89421-PEP
GeneTex
Product group Proteins / Signaling Molecules
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    ERG blocking peptide
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Scientific Description
    This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewings sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352202