Erlotinib [183321-74-6]

MedChem Express

Erlotinib [183321-74-6]

10

183321-74-6

CHEMICAL,general_chemicals_reagents

Research Use Only

99.99

C22H23N3O4

393.44

Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1]. Erlotinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

C#CC1=CC=CC(NC2=NC=NC3=C2C=C(C(OCCOC)=C3)OCCOC)=C1

-20°C, 3 years; 4°C, 2 years (Powder)

12352005