Ethaselen [217798-39-5]

MedChem Express

Ethaselen [217798-39-5]

10

217798-39-5

Research Use Only

98.0

C16H12N2O2Se2

422.20

Ethaselen (BBSKE) is an orally active, selective thioredoxin reductase (TrxR) inhibitor with IC50s of 0.5 and 0.35 microM for the wild-type human TrxR1 and rat TrxR1, respectively. Ethaselen specifically binds to the unique selenocysteine-cysteine redox pair in the C-terminal active site of mammalian TrxR1. Ethaselen, an organoselenium compound, is a potent antitumor candidate that exerts potent inhibition on non-small cell lung cancer (NSCLC) by targeting TrxR[1][2].

O=C1N([Se]C2=CC=CC=C12)CCN3[Se]C4=CC=CC=C4C3=O

-20°C,2°C to 8°C

12352200