Evolocumab

MedChem Express

Evolocumab [1256937-27-5]

10

Research Use Only

Monoclonal

98.40

Evolocumab (AMG 145) is a human monoclonal antibody that inhibits PCSK9 . Evolocumab is used in the study of hypercholesterolemia and atherosclerotic cardiovascular disease. Evolocumab binds to circulating PCSK9 protein and inhibits its binding to LDLR. Evolocumab has antioxidant and cytoprotective activities against H 2 O 2 -induced oxidative damage to endothelial cells. Evolocumab may also negatively regulate activation of the TLR-4/NF-kappaB signaling pathway to prevent inflammation [1] [2] [3] .

2°C to 8°C

12352203