Western blot All lanes: EYA3 antibody at 1.49microg/ml Lane 1: Hela whole cell lysate Lane 2: 293T whole cell lysate Lane 3: HT29 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 63, 49, 59, 57, 58 kDa Observed band size: 63 kDa

EYA3 Antibody

Name: EYA3 Antibody
SKU: CSB-PA860766DSR1HU_C90
Availability: BackOrder

CSB-PA860766DSR1HU

ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry

Product group Antibodies

TargetEYA3

Overview

Supplier
Cusabio
Product Name
EYA3 Antibody
Delivery Days Customer
20
Applications
Western Blot, ELISA, ImmunoHistoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID2140
Target name
EYA3
Target description
EYA transcriptional coactivator and phosphatase 3
Target synonyms
eyes absent 3; eyes absent homolog 3
Host
Rabbit
Isotype
IgG
Protein IDQ99504
Protein Name
Eyes absent homolog 3
Scientific Description
Tyrosine phosphatase that specifically dephosphorylates Tyr-142 of histone H2AX (H2AXY142ph). Tyr-142 phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye.
Storage Instruction
-20°C or -80°C
UNSPSC
12352203

EYA3 Antibody

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Overview

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