(E/Z)-Afatinib (Standard) [439081-18-2]
HY-10261BR
Product group Assays
Overview
- SupplierMedChem Express
- Product Name(E/Z)-Afatinib (Standard) [439081-18-2]
- Delivery Days Customer5
- CAS Number439081-18-2
- CertificationResearch Use Only
- Molecular FormulaC24H25ClFN5O3
- Molecular Weight485.94
- Scientific Description(E/Z)-Afatinib (Standard) is the analytical standard of (E/Z)-Afatinib. This product is intended for research and analytical applications. (E/Z)-Afatinib ((E/Z)-BIBW 2992) is the mixture of (E)-Afatinib and (Z)-Afatinib. Afatinib (HY-10261) is an irreversible inhibitor of EGFR, by irreversibly binding to their ATP binding site to block activation of EGFR, HER2, HER4, and EGFRvIII. Afatinib used in co-administration with Temozolomide (HY-17364), potently targeting to EGFRvIII-cMet signaling in glioblastoma cells[1].
- SMILESO=C(/C=C/CN(C)C)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1O[C@@H]4COCC4
- UNSPSC41116135